Rat periodontal ligament cell에서의 RANKL mRNA의 발현
Expression of mRANKL in rat PDL cell
소속 상세정보
김현수
정현주/김영준/김옥수
KMID : 0363020040340020367
Abstract
As the periodontal ligament cells show similar phenotype with osteoblasts, periodontal ligament cells are thought to play an important role in alveolar bone remodeling. According to recent studies, receptor activation of nuclear factor κB ligand (RANKL) and osteoprotegerin (OPG) are expressed in periodontal ligament cells during tooth movement. Also periodontal ligament cells is known to play an important role in the progression of periodontal disease.
This study was designed how the expression of RANKL and OPG in periodontal ligament cells was regulated by IL-1β in the concentration of 0.01~10 ng/ml.
The results are as follows;
1. Periodontal ligament cells which stimulated by IL-1β increased soluble RANKL synthesis by dose-dependent pattern in the concentration of 0.01~10 ng/ml.
2. IL-1β induced mRANKL expression in dose-dependent manner in the concentration of 0.01~5 ng/ml.
3. mOPG expression was not to be influenced by IL-1β.
These results suggested that rat periodontal ligament cells could regulate osteoclastogenesis by stimulation of production of RANKL.
키워드
RANKL;OPG;periodontal ligament cell
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